These tools integrates with
OpenAI APIvsAutoGen⚠ Stale
GPT-5 era models, embeddings, and Responses API from OpenAI versus Conversational multi-agent framework — superseded by Microsoft Agent Framework
Compare interactively in Explore →Choose OpenAI API when…
- •You need the broadest ecosystem and most integrations
- •GPT-4 or o-series reasoning models are required
- •Assistants API, fine-tuning, or batch API are needed
Choose AutoGen when…
- •You want conversational multi-agent orchestration
- •Research or Microsoft ecosystem integration matters
- •You need flexible human-in-the-loop patterns
Side-by-side comparison
Field
OpenAI API
AutoGen
Category
LLM Infrastructure
Agent Frameworks
Type
Commercial
Open Source
Free Tier
✗ No
✓ Yes
Pricing Plans
API: Per token
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GitHub Stars
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⭐ 34,000
Health
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●60 — Slowing
OpenAI API
API access to GPT-5, GPT-5.5, o3/o4 reasoning models, and the Responses API; plus embeddings, image, audio, and Realtime endpoints. The most widely deployed LLM API in production.
Shared Connections5 tools both integrate with
Only OpenAI API (34)
LlamaIndexPydanticAIsmolagentsHeliconeMistral APICohere APIGroqTogether AIVercel AI SDKAutoGen
Only AutoGen (2)
OpenAI APIMicrosoft Agent Framework
Explore the full AI landscape
See how OpenAI API and AutoGen fit into the bigger picture — 256 tools, 553 relationships, all mapped.