OpenAI Agents SDK
OpenAI's production-grade agent framework, successor to Swarm. Core abstraction is explicit handoffs between agents carrying full context. Built for reliable multi-agent pipelines with native OpenAI tool use, tracing, and guardrails.
Strands Agents
AWS's open-source Python SDK for building production AI agents. Uses a model-driven approach where tools are described and the model reasons about their use. Native Mem0 integration for persistent memory, MCP support, and multi-agent coordination out of the box.